Bibu John Kariyil

Kerala Veterinary and Animal Sciences University, India

Title: Advancing Triple Negative Breast Cancer Treatment: Phytochemicals as Potential Therapeutic Agents


Triple-negative breast cancer (TNBC) is a challenging subtype of breast cancer due to the lack of estrogen, progesterone, and HER2 receptors, which makes traditional hormone therapies ineffective. However, the exploration of phytochemicals as potential therapeutic agents has shown promise in the treatment of TNBC. Rigorous scientific investigation has revealed the anticancer efficacy of natural compounds found in plants such as Annona muricata, Erythrina variegata, Artocarpus hirsutus and more. These compounds have been found to disrupt critical cellular pathways in TNBC cells, including those regulating apoptosis and cell cycle progression. Additionally, they interfere with cancer cell signaling, promoting cell death and inhibiting tumor growth. The enhanced understanding of phytochemical interactions with cancerous cells underscores the potential for integrating these natural compounds into the broader strategy of TNBC treatment, leveraging their specificity and reduced toxicity for more effective and patient-friendly therapies. Furthermore, natural compound-based standalone or combination therapy could be utilized for the better management of TNBC, as these compounds are known for their minimal side effects and cost-effectiveness. Clinical trials have shown varying degrees of effectiveness, and while in vivo and in vitro data are promising, further basic and clinical investigations are required. The use of natural products in combination with other drugs may hold great potential for the treatment of TNBC. 
The research and development of nature-derived molecules underscore the vital role of natural products in the future of oncological treatment, especially in targeting challenging subtypes such as TNBC., Therefore, the exploration of natural compounds as potential therapeutic agents represents a promising advance in the treatment of TNBC, offering hope for the development of more effective and patient-friendly therapies.


Dr. Bibu John Kariyil is a distinguished Assistant Professor and Course Director in the Department of Veterinary Pharmacology & Toxicology at the Faculty of Veterinary and Animal Sciences of Kerala Veterinary and Animal Sciences University, Kerala, India. His impressive educational background includes a Bachelor of Veterinary Sciences & Animal Husbandry, M.V.Sc. in Veterinary Pharmacology & Toxicology, Ph.D. in the same field, and an MBA, among other qualifications. Dr. Kariyil has a broad range of professional experience, including roles as a Veterinary Surgeon and Research Associate in various capacities. His research contributions are substantial, with principal investigator roles in multiple funded projects. Dr. Kariyil's work has led to advancements in the evaluation of medicinal plants for wound healing, anticancer activity, and the revamping of laboratory animal facilities, among other areas. His commitment to education and research is further evidenced by his involvement in workshops, training programs, and advisory roles for postgraduate and doctoral research. Dr. Kariyil's contributions to veterinary science are also recognized through numerous awards and honors, including the Dr. M. Krishnan Nair Award for Best Teacher, and recognitions for his research articles and presentations.