Breast cancer is one of the most widespread malignancies and the leading cause of death globally. Breast cancer patients with low survival rates are attributed towards the genomic alterations of specific targets such as EGFR, ER and DNA repair check-point-sensor genes. Identification of specific high frequency mutation(s) needs utmost attention due to their involvement in the aggressive behavior of this cancer and one of the contributing factors for the low survival rates. Further the non-coding RNAs and their roles in regulating these targets or the DNA repair mechanism is an emerging area of biomedical research to address some of the unanswered questions. However, it is not only necessary to identify the high frequency genomic alterations and regulatory molecules/targets but also important to address at the molecular interaction level, molecular dynamic simulations and the network of these interactions to evaluate the stability of interacting molecules. This ensures to develop strong link at the molecular level which might address and translates to the overall physiological/metabolic changes during the breast cancer progression. Hence, our labs efforts for understanding some of such links and the analysis of the chemical/molecular entities and molecular dynamic interactions at different levels of the genomic variant targets and DNA repair mechanisms would provide a versatile platform for the overall diagnostic and therapeutic approaches.

Pramod Kumar Avti, currently additional professor, department of biophysics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. He was a research associate at department of electrical engineering, biomedical engineering divisions, laboratory of molecular imaging, ecole polytechnique and department of chemistry, McGill University, Montreal. He was a postdoctoral associate at the department of biomedical engineering, ecole polytechnique, Montreal, and also postdoctoral fellow at departments of biomedical engineering, Stony Brook University, New York, USA. He earned many national and international awards for his research in developing innovative integrative approaches as platforms for a variety of biomedical applications – Translational and Molecular Imaging Award, Mount Sinai School of Medicine, New York and Young Investigator Award to name a few. He published more than 120 peer reviewed high impact international research articles, reviews, books and book chapters. He is also the editorial board member of 4 international journals and is an active reviewer since 2010 for more than 30 internationals journals. He is also member of various international and national scientific societies. He has delivered more than 50 invited lectures at various national and international conferences/meetings/workshops. Recently, he is honored as a Fellow of International Medical Science Academy (FIMSA) and an elected member of National Academy of Medical Sciences (NAMS). He is one of the active members in driving the new center for Integrative Medicine for Mind-Body intervention in collaboration with the CCRYN, at PGIMER, Chandigarh. His current research interests include breast cancer biomarkers, translational medicine, small molecules identification, molecular integration systems development for rapid diagnostic and therapeutic strategies in various biomedical applications.