Rahul Hajare

Sandip University, India

Title: Breast cancer and Indole-3-Carbinol: Medicinal development and strategies of natural products


Estrogen-responsive breast cancer cells, such as MCF7 and T47D cells, express both estrogen receptor ER and ERß. Indole-3-carbinol (I3C) strongly down-regulated ER protein and transcript levels, without altering the level of ERß protein, in both cell lines. In cells transfected with the ER promoter linked to a luciferase gene reporter, I3C ablated ER promoter activity1-5. Dietary indole-3-carbinol prevents the development of estrogen-enhanced cancers including breast. Whereas estrogen increases the growth and survival of tumors, indole-3-carbinol causes growth arrest and increased apoptosis and ameliorates the effects of estrogen. In these findings best use indole-3-carbinol together with other nutrients (genistein) to achieve maximum benefits for cancer prevention. Investigator evaluated whether genistein, which is the major isoflavonoid in soy, would alter the ability of indole-3-carbinol/DIM to cause apoptosis and decrease expression driven by the estrogen receptor (ER)-alpha.


Dr. Rahul Hajare received his B.Pharm. degree in 2002 from Amravati University in India, where he studied pharmaceutical chemistry. After that, he joined the research team at Nagpur University's Institute of Pharmaceutical Research, Education, and Quality Assurance. In 2012, he graduated from Vinayaka Mission University with a PhD after completing two years of postdoctoral research at the National AIDS Research Institute (ICMR) in Pune, India, under the supervision of renowned and highly respected scientist Dr. Ramesh Paranjape. In Nashik, he is named a professor at Sandip University, School of Pharmaceutical Science. In SCI (E) journals, he has over 70 research publications to his credit. The Scholar Hindu University of America, Florida, presents Dr. Rahul Hajare with an award.