The Retrospective study aimed to assess the prognostic significance of tumor-infiltrating lymphocytes (TILs) and peripheral inflammatory markers in early-stage triple-negative breast cancer (TNBC) patients treated with neoadjuvant chemotherapy. Forty Three patients included, with baseline TILs evaluated on biopsies. Higher baseline TIL levels were significantly associated with higher rates of pathological complete response (pCR). Elevated peripheral inflammatory markers, were correlated with lower pCR rates and poorer event-free survival (EFS). Local tumor immune infiltration may relate to systemic inflammatory status. In multivariate analysis, high TIL levels and low NLR remained independent predictors of favorable outcomes.

Dr. Sanz , MD is a Medical Oncologist specialized in breast cancer who currently leads the Southern Tenerife Oncology Department. He is dedicated to advancing modern, patient-centered cancer care. In addition to his clinical work, Dr. Sanz is committed to patient education and awareness through his active presence on social media, where he shares valuable information on breast cancer to improve understanding and support shared decision-making.