5-Fluoroacil (5-FU)-based chemotherapy has been widely used in the treatment of different cancer in adjuvant and metastatic settings. The common side effects related to 5-FU are gastrointestinal toxicity including nausea, vomiting, diarrhea, and stomatitis as well as myelosuppression, hand-and-foot syndrome, and coronary vasospasm. In the medical literature, only rare cases of 5-FU-related encephalopathy are reported. We report a 51-year-old male patient with gastric adenocarcinoma who developed acute neurotoxicity and recurrent seizures after he underwent the first session of 5-FU chemotherapy treatment. Neurotoxicity is an important complication due to 5-FU and should not be overlooked when the patient is being treated with this chemotherapeutic agent, alone or in combination with other drugs. It runs an unpredictable course and may result in significant morbidity and mortality. The supportive and symptomatic management should be considered to avoid complications related to neurological side effects.

Aed Abdelqader Mari Banibakr is a highly qualified and experienced nurse with a diverse background in healthcare. He earned his baccalaureate degree in nursing from Mutah University, Jordan, in 2010, and later pursued a master's degree in nursing science from UNISZA, Malaysia, graduating in 2020. He has dedicated several years to providing direct nursing care in various clinical settings, particularly in ICU/CCU units. His expertise includes developing comprehensive care plans, administering medications, conducting nursing assessments, and ensuring the safety and well-being of patients. He is not only a seasoned practitioner but also a dedicated researcher, having conducted studies on nurses' job performance and job satisfaction in Jordanian Public Hospitals. His commitment to advancing the nursing profession is evident through his published articles in peer-reviewed journals and his role as a presenter at the National Conference of Science and Social Sciences in 2018. He possesses a range of skills, including proficiency in data analysis, teamwork, and computer skills, making him a valuable asset to any healthcare team. Additionally, he actively engages in continuous education, as demonstrated by his participation in various courses and training programs. His multifaceted experience, commitment to research, and dedication to professional development showcase his passion for delivering high-quality patient care and contributing to the advancement of nursing knowledge and practices.