METHODOLOGY: The method is using a special algorithm based in math which allows to find disease causes for a specific non-infectious disease using results of multiple researches regarding risk factors of the disease. This method allows to combine dozens of such researches together with dozens of researches on biochemistry and physiology to extract implicit information on the causes of non-infectious disease out this entire research. The method often allows to find few dozen of disease causation factors and more for a non-infectious disease out of known risk factors. These disease causation factors all point to the same unique set of limited number of physiological changes approximately beyond 1-sigma. The number of these physiological changes usually vary depending on the non-infectious disease from a minimum of 2 to a maximum of 6 or very rare more. The method allows to determine which physiological parameters are impacted by each of the dozens of disease causation factors previously found. These 2 to 6 physiological changes coexisting at the same time long enough must( it is not optional) trigger a non-infectious disease.

Using this method and applying over 29 existing selected studies at the same time an author analyses Breast Cancer and as a result the work concludes that next unique combination of physiological parameters changes beyond 1- sigma interval (slightly less, actually) causes Breast Cancer if the changes coexist long enough. This combination for Breast Cancer consist of 4 physiological changes which should coexist at the same time: Increased DNA strand breaks (beyond 1-sigma), TNF-alfa increased (beyond 1-sigma), Leptin level increase(beyond 1-sigma), High estradiol (beyond 1-sigma). This unique physiological changes can be triggered by multiple different combinations of external factors and this fact creates a visible randomness in a Breast Cancer pathology... Also, as usual the method allowed systematically create a detailed hypothesis of Breast Cancer pathology. At the very high level this hypothesis states that the disruption of natural DNA damage/DNA repair homeostasis leads to a Breast Cancer.