Breast cancer is a frequently encountered malignancy in females, with its incidence influenced by a variety of factors. Among its subtypes, triple-negative breast cancer (TNBC) tends to have a more aggressive clinical course and limited treatment options. Cutaneous metastasis with squamous differentiation is an uncommon manifestation typically associated with advanced or recurrent disease. We report the case of a 63-year-old female previously diagnosed and treated for TNBC in Syria, who later presented to our institution with advanced disease. Despite further management efforts, the disease progressed rapidly, and the patient ultimately passed away. This case highlights the aggressive nature of certain breast cancer subtypes and the importance of recognizing atypical metastatic presentations.

Ameera is a recent medical graduate from Dubai Medical university and currently completing her internship at Kings Hospital Dubai. Her clinical interests particularly lie in women’s health, surgery, and the evolving field of global surgery. Throughout her medical training, she has demonstrated a strong commitment to research, reflecting her commitment for evidence-based practice and innovation in patient care. Beyond her clinical pursuits, She has been involved in initiatives promoting responsible antibiotic use within healthcare settings addressing the global threat of antimicrobial resistance (AMR).