Isolated locoregional recurrence (ILRR) in breast cancer refers to recurrence limited to the ipsilateral chest wall and/or regional lymph nodes without evidence of distant metastasis within four months. While ILRR uncommon, it has important prognostic and therapeutic implications, particularly in resource-limited settings. The incidence and biological behavior of ILRR may vary across populations, requiring context-specific data to guide clinical decisions

OBJECTIVE: To analyze the clinical patterns, risk factors, and treatment strategies for ILRR in post-mastectomy breast cancer patients at a tertiary care hospital in South India.

METHODS: This retrospective study reviewed 75 patients who developed ILRR following mastectomy between 2012 and 2017. All cases were evaluated for nodal involvement, histological subtype, surgical margin status, hormone receptor status, and biological subtype at initial diagnosis. Advanced imaging, including MRI, ultrasound, and PET-CT, was used to exclude distant metastases. Patterns of recurrence and treatment outcomes were documented and analyzed.

Dr. Shalini Duvvada, MBBS, MS (General Surgery), MRCS (England), is a Consultant Surgeon and Assistant Professor at King George Hospital and Andhra Medical College, Visakhapatnam. She specializes in breast surgery and has established a dedicated Breast Health Centre in Northeast Andhra Pradesh. Dr.Shalini Duvvada completed a clinical attachment in breast radiology at St. George's University Hospitals, London. Her work focuses on breast cancer diagnosis, oncoplastic surgery, and improving patient outcomes. She is actively involved in clinical research, with a special interest in locoregional recurrence after mastectomy. Dr. Duvvada is committed to advancing breast cancer care and education in India through clinical excellence and research.