Paraneoplastic pemphigus is a rare autoimmune blistering dermatosis, associating erosive stomatitis, polymorphic rash and neoplasia, known or revealed at the time of PNP diagnosis. Cases of PNP associated with solid cancer are extremely rare. The association with prostate adenocarcinoma remains exceptional. We report an anusual case of recalcitrant paraneoplastic pemphigus revealing a prostatic adenocarcinoma, rapidly regressing after associating hormonotherapy with conventional immunosuppressive therapy suggesting the efficiency of androgen deprivation as an  adjuvant therapy of PNP in men presenting an underlying prostatic adenocarcinoma.