Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. It is the most rambling communicable infectious disease on earth and remains out of control in many developing countries. It is the single most common cause of death in individuals aged 15-49 years. India features among the 22 high TB burden countries and has accounted for an estimated one-quarter (26%) of all TB cases worldwide. Pulmonary tuberculosis is the most common presentation among all. Good bacteriological diagnosis and compliance with treatment are the two core stakes of successful treatment of pulmonary tuberculosis. 

Materials and Methods: A prospective study was carried out from January 2020 - December 2020 during which the data was collected from a total of 200 case sheets of the inpatients of all departments (except OBG) of a tertiary care hospital. All the case sheets were checked for Drug Related Problems (DRPs) by using Micromedex, Drugs.com database and various standard textbooks along with interview from patients and evaluated as per PCNE classification. 

Results: The data was collected from 200 in-patients using a specially designed data collection form. Out of 200 patients, 90 patients with hepatic impairment, 60 with diabetes, 34 with lower respiratory tract infection, 10 with hypertension & 6 with chronic obstructive pulmonary disease were found. In this study, a total of 1170 DRPs have been identified in 200 patients by using 6 categories of “Pharmaceutical Care Network Europe” (PCNE) DRPs classification. Drug interactions (50.26%) were the most common drug related problems found, which was clinically significant in tuberculosis patients with comorbidities. Drug choice problem (40.68%) was the second most common drug related problem found, which consists of inappropriate use of drugs (74.37%) like antibiotics and acid suppressant drugs. Hepatic impairment was common ADR found in most of the tuberculosis patients on anti-tubercular drugs. But in future we need to pay more attention to the management of tuberculosis in patients suffering from diabetes, hypertension and other comorbidities and associated drug related problems. 

Conclusion: A substantial proportion of hospitalized patients experience medication-related harm that is preventable. Medication errors have been estimated to account for over a quarter of the causes of adverse drug events. Strategies to prevent such problems are being developed. One such strategy is that the complete clinical status of each patient is considered while identifying drug related problems & the structured review of patient medication by clinicians is done to identify patients with medication errors that may otherwise lead to harm. 

Keywords: Tuberculosis, PCNE classification, Drug interactions, Hypertension, Drug related problems.