It is well established that hormones in general and sex hormones in particular are coordinators of the well-being of Women, since their embryonic phase up to menopause. A woman is fortunate in that her ovarian estrogen helps to keep her in healthy state by regulating 300 metabolic functions. Concurrently a woman is unfortunate after menopause since her ovaries become dysfunct, the estrogen titer surges to a low ebb so also the progesterone and subjected to breast cancer. Breast cancer continues to rise due to exogenous, endogenous factors and self-lifestyles.

According to Journal of National Cancer Institute, the risk of breast cancer by the time a woman reaches the age of 50 and menopause is one in 49 and one in 10 at 80. Extra-ovarian estrogens and cumulative buildup of environmental xeno-estrogens manifest more and more breast cancers and less and less survival chances. Due to the estrogen dominance and progesterone down regulation, women are comparable to sinking titanic in spite of conventional therapies in vogue. 

The major roadblocks to ERT/ HRT in breast cancer include receptor status; Receptor counts, familial manifestation, oncogenes expressions, stem cells dynamics, failure to activate P53; Synthetic estrogens, estrogen dominance; Global warning backlash, Premenopausal – Postmenopausal calamities; stress factors etc.