Maykon Jhuly Martins de PaivaUniversity of Gurupi , Brazil
Title: Use of Medicinal Plants in the Treatment of Breast Cancer: Perspectives
Breast cancer is one of the leading causes of female mortality worldwide, stimulating the search for more effective and milder treatment options. Medicinal plants have emerged as a promising avenue, with compounds like curcumin, lupeol, quercetin, and Epigallocatechin gallate (EGCG) showing potential therapeutic properties. Curcumin, found in turmeric, has attracted considerable attention due to its anti-inflammatory, antioxidant, and antitumor properties, inhibiting cell proliferation and suppressing angiogenesis. Lupeol, present in various plants, also exhibits anticancer potential, inhibiting cell progression and promoting apoptosis in breast cancer cells. Quercetin, a flavonoid found in fruits and vegetables, also has anticancer effects, inducing apoptosis and inhibiting cell proliferation. Similarly, EGCG, found in green tea, inhibits cell growth, angiogenesis, and modulates signaling pathways related to breast cancer. Despite promising results in preclinical studies, caution is crucial. More comprehensive investigations, including clinical trials involving humans, are needed to verify the safety and efficacy of curcumin and lupeol as breast cancer treatments before integrating them into conventional practice. The use of medicinal plants and their active constituents represents a hopeful and novel direction in the search for alternative therapies for breast cancer, with potential for significant advances in managing this devastating disease and improving patient outcomes.
Maykon Jhuly Martins de Paiva is a Ph.D. candidate in Pharmaceutical Sciences at the University of Brasília, Brazil. He is the head of the Pharmacology Department at the University of Gurupi, in the Medicine course at the Paraíso do Tocantins Campus. He has scientific publications worldwide and has been serving as a reviewer for several scientific journals, as well as coordinating research and university extension projects.